Sheikh Zayed City is situated about 20 km (12 mi) from Lebanon Square in the Mohandiseen district of Giza. It is bordered to the north by the Cairo-Alexandria desert road, to the south by the 26 July Corridor, and to the west by the neighboring 6th of October.

The city forms part of the Giza Governorate, and is divided into 17 residential districts, with four neighborhoods in each district. 

Sheikh Zayed City sits 226 meters above mean sea level.